Across TCGA pan-cancer cohorts, SPDYE12P RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SPDYE12P data layer.
The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SPDYE12P RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPDYE12P expression acts as an unfavorable survival marker, although some lineages such as LAML and BLCA show a favorable association.
ACC, COAD, and MESO are the cancer types where SPDYE12P RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.