Across TCGA patient cohorts, SPDYC mutation is significantly associated with the RNA expression of many other genes, with 1,166 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPDYC-associated genes across cancer lineages are SAPCD2P2, SRIP3, and OR4A50P. Each is linked with SPDYC in more than 2 cancer types. Because this analysis shows association rather than direction, both SPDYC-to-partner and partner-to-SPDYC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDYC→partner) and Y-score (partner→SPDYC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SAPCD2P2 →	+0.044	+2.640	.001	.003	3	3
UCEC	SRIP3 →	+0.551	+3.516	<.001	<.001	3	2
CESC	OR4A50P →	+0.085	+4.969	<.001	.004	3	2
UCEC	CYP4F36P →	+0.312	+2.690	.001	.001	3	2
UCEC	RNA5SP412 →	+0.736	+2.552	<.001	.002	3	2
UCEC	SPDYE20P →	+0.246	+2.569	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,166 associations by consensus.

Exploration

SPDYC survival (RNA) · tumor vs normal (RNA) · all SPDYC data types