Across TCGA cell cohorts, SPDYC mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPDYC-associated genes across cancer lineages are ADIG, OR4F15, and MAGEB4. Each is linked with SPDYC in more than 1 cancer types. Because this analysis shows association rather than direction, both SPDYC-to-partner and partner-to-SPDYC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDYC→partner) and Y-score (partner→SPDYC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ADIG →	+0.065	+5.029	<.001	.006	3	1
LUNG_SCLC	OR4F15 →	+0.029	+5.029	<.001	.006	3	1
LARGE_INTESTINE	MAGEB4 →	+0.024	+6.000	<.001	<.001	3	1
LARGE_INTESTINE	CSN2 →	+0.024	+4.684	.003	.002	3	1
LARGE_INTESTINE	STRA8 →	+0.161	+4.415	<.001	.007	3	1
LARGE_INTESTINE	ZNF804B →	+0.016	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

SPDYC survival (RNA) · tumor vs normal (RNA) · all SPDYC data types