SPDYA

Across TCGA pan-cancer cohorts, SPDYA Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SPDYA data layer compared with 25 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher SPDYA Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPDYA expression acts as an unfavorable survival marker.

STAD, ACC, and PCPG are the cancer types where SPDYA Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	II,III,IV	0.003	0.677	<.001	24	view →
ACC	OS	Median	All	0.113	0.822	<.001	21	view →
PCPG	DFS	Median	All	0.080	0.768	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SPDYA–STAD (OS)

Open the STAD breakdown →