SPDL1

Across TCGA patient cohorts, SPDL1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPDL1-associated genes across cancer lineages are PDCD4, 4E-BP1_pT37_T46, and EGFR. Each is linked with SPDL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPDL1-to-partner and partner-to-SPDL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by SPDL1-low versus SPDL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDL1→partner) and Y-score (partner→SPDL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.564	-2.405	.001	.003	3	2
UCEC	4E-BP1_pT37_T46 →	-0.427	-3.794	.001	<.001	3	2
UCEC	EGFR →	-0.186	-1.847	.001	.008	3	1
UCEC	eIF4G →	+0.241	+2.999	.035	.035	3	1
UCEC	FoxM1 →	+0.229	+2.736	.016	<.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.114	-1.896	.012	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

PDCD4 by SPDL1 expression — UCEC

Explore this box plot interactively →