SPDL1

Across TCGA cell cohorts, SPDL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,209 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPDL1-associated GO terms across cancer lineages are Negative regulation of sister chromatid segregation, Negative regulation of mitotic sister chromatid segregation, and Negative regulation of mitotic metaphase/anaphase transition. Each is linked with SPDL1 in more than 18 cancer types. Because this analysis shows association rather than direction, both SPDL1-to-partner and partner-to-SPDL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of sister chromatid segregation grouped by SPDL1-low versus SPDL1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDL1→partner) and Y-score (partner→SPDL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of sister chromatid segregation →	+0.193	+1.942	<.001	<.001	3	19
LUNG_NSCLC_LUSC	Negative regulation of mitotic sister chromatid segregation →	+0.193	+1.942	<.001	<.001	3	19
LUNG_NSCLC_LUSC	Negative regulation of mitotic metaphase/anaphase transition →	+0.193	+1.942	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Mitotic spindle assembly checkpoint signaling →	+0.185	+1.356	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Spindle assembly checkpoint signaling →	+0.185	+1.356	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Mitotic spindle checkpoint signaling →	+0.185	+1.356	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,209 associations by consensus.

Negative regulation of sister chromatid segregation by SPDL1 expression — LUNG_NSCLC_LUSC

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