SPDL1

Across TCGA cell cohorts, SPDL1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPDL1-associated genes across cancer lineages are EXOC1L, TTLL8, and WDR87. Each is linked with SPDL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPDL1-to-partner and partner-to-SPDL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EXOC1L grouped by SPDL1-low versus SPDL1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDL1→partner) and Y-score (partner→SPDL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	EXOC1L →	+0.036	+4.906	<.001	.006	3	1
LARGE_INTESTINE	TTLL8 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	WDR87 →	+0.017	+3.453	.003	.009	3	1
LARGE_INTESTINE	OR52H1 →	+0.032	+3.347	<.001	.005	3	1
LARGE_INTESTINE	LILRB5 →	+0.069	+4.491	<.001	<.001	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

EXOC1L by SPDL1 expression — OESOPHAGUS

Explore this box plot interactively →