SPDL1

Across TCGA cell cohorts, SPDL1 mutation is significantly associated with the mutation status of many other genes, with 2,188 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPDL1-associated genes across cancer lineages are PCBP2, ZNF14, and ALDH3B2. Each is linked with SPDL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPDL1-to-partner and partner-to-SPDL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCBP2 grouped by SPDL1-low versus SPDL1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDL1→partner) and Y-score (partner→SPDL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PCBP2 →	+4.309	+4.560	.007	.007	1	3
BLOOD_Lymphoma	ZNF14 →	+4.584	+4.584	.007	.007	1	3
BLOOD_Lymphoma	ALDH3B2 →	+4.584	+4.584	.007	.007	1	3
BLOOD_Lymphoma	PCNX2 →	+3.847	+5.108	.001	.001	1	3
BLOOD_Lymphoma	MMUT →	+4.584	+4.584	.007	.007	1	3
BLOOD_Lymphoma	MS4A2 →	+4.584	+4.584	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,188 associations by consensus.

PCBP2 by SPDL1 expression — BLOOD_Leukemia

Explore this box plot interactively →