SPDEF

Across TCGA pan-cancer cohorts, SPDEF mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SPDEF data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SPDEF mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SPDEF expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC and PDAC are the cancer types where SPDEF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.944	0.815	.045	6	view →
PDAC	DFS	Median	All	0.350	0.827	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SPDEF–UCEC (DFS)

Open the UCEC breakdown →