SPDEF

Across TCGA patient cohorts, SPDEF RNA expression is significantly associated with the protein abundance of many other proteins, with 16,529 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SPDEF-associated proteins across cancer lineages are MLPH, AGR2, and TC2N_S156. Each is linked with SPDEF in more than 6 cancer types. Because this analysis shows association rather than direction, both SPDEF-to-partner and partner-to-SPDEF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPDEF versus MLPH in BRCA, with a Pearson correlation of 0.73.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDEF→partner) and Y-score (partner→SPDEF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MLPH →	+0.990	+2.734	<.001	<.001	3	7
BRCA	AGR2 →	+1.245	+2.743	<.001	<.001	3	7
LUAD	TC2N_S156 →	+1.221	+1.272	<.001	<.001	3	7
UCEC	MUC5B →	+1.620	+1.814	<.001	<.001	2	7
LUAD	PDXDC1 →	+0.390	+1.174	<.001	<.001	3	6
OV	TJP3_S203 →	+0.955	+1.738	.004	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,529 associations by consensus.

SPDEF vs MLPH — BRCA

Explore this scatter interactively →