SPDEF

Across TCGA patient cohorts, SPDEF mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPDEF-associated genes across cancer lineages are VHL, p21, and ERK2. Each is linked with SPDEF in more than 1 cancer types. Because this analysis shows association rather than direction, both SPDEF-to-partner and partner-to-SPDEF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by SPDEF-low versus SPDEF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDEF→partner) and Y-score (partner→SPDEF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-1.140	-3.000	.002	.036	3	1
SKCM	p21 →	-0.585	-2.982	.018	.036	2	1
UCEC	ERK2 →	+0.271	+3.169	.010	.020	1	1
UCEC	STAT3_pY705 →	-0.379	-3.169	.008	.020	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

VHL by SPDEF expression — UCEC

Explore this box plot interactively →