SPDEF

Across TCGA cell cohorts, SPDEF RNA expression is significantly associated with the go_rna of many other GO terms, with 3,370 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible SPDEF-associated GO terms across cancer lineages are Cilium or flagellum-dependent cell motility, Lateral line system development, and Body fluid secretion. Each is linked with SPDEF in more than 7 cancer types. Because this analysis shows association rather than direction, both SPDEF-to-partner and partner-to-SPDEF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cilium or flagellum-dependent cell motility grouped by SPDEF-low versus SPDEF-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDEF→partner) and Y-score (partner→SPDEF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Cilium or flagellum-dependent cell motility →	-0.082	-4.187	<.001	<.001	3	8
PANCREAS	Lateral line system development →	+1.557	+2.528	<.001	<.001	3	8
STOMACH	Body fluid secretion →	+0.163	+2.481	<.001	<.001	3	8
PANCREAS	Acetylcholine biosynthetic process →	+1.594	+2.573	<.001	<.001	3	8
BREAST	Cilium-dependent cell motility →	-0.082	-4.187	<.001	<.001	3	8
LARGE_INTESTINE	Cilium movement involved in cell motility →	-0.074	-1.500	.002	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,370 associations by consensus.

Cilium or flagellum-dependent cell motility by SPDEF expression — BREAST

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