SPCS3

Across TCGA pan-cancer cohorts, SPCS3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SPCS3 data layer compared with 28 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SPCS3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SPCS3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where SPCS3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	1.000	0.380	.027	12	view →
LUAD	OS	Quartile	All	1.000	0.613	.008	4	view →
LSCC	DFS	Tertile	II,III,IV	0.580	0.890	.037	3	view →
PDAC	OS	Quartile	III,IV	0.594	1.000	.045	2	view →
CCRCC	OS	Quartile	All	0.580	1.000	.024	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SPCS3–HNSC (DFS)

Open the HNSC breakdown →