SPCS3

Across TCGA patient cohorts, SPCS3 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,075 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPCS3-associated proteins across cancer lineages are COQ6, NUCB2, and TIMM8A. Each is linked with SPCS3 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPCS3-to-partner and partner-to-SPCS3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPCS3 versus COQ6 in OV, with a Pearson correlation of -0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPCS3→partner) and Y-score (partner→SPCS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	COQ6 →	-0.329	-0.683	.002	<.001	3	4
COAD	NUCB2 →	+0.465	+0.513	.002	.001	3	4
COAD	TIMM8A →	-0.390	-0.424	<.001	<.001	3	4
LSCC	TRMT10C →	-0.352	-0.491	<.001	<.001	3	4
BRCA	TFB2M →	-0.536	-0.536	<.001	<.001	3	4
LUAD	CHKB →	+0.296	+0.344	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,075 associations by consensus.

SPCS3 vs COQ6 — OV

Explore this scatter interactively →