SPCS3

Across TCGA patient cohorts, SPCS3 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPCS3-associated genes across cancer lineages are ATM, CD49b, and p27_pT198. Each is linked with SPCS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPCS3-to-partner and partner-to-SPCS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SPCS3-low versus SPCS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPCS3→partner) and Y-score (partner→SPCS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.471	-3.321	.047	.010	3	1
UCEC	CD49b →	+0.371	+2.183	.012	.035	3	1
UCEC	p27_pT198 →	+0.128	+3.000	.022	.036	2	1
UCEC	S6_pS240_S244 →	+0.566	+3.321	.007	.010	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ATM by SPCS3 expression — UCEC

Explore this box plot interactively →