SPCS3

Across TCGA cell cohorts, SPCS3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,339 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SPCS3-associated GO terms across cancer lineages are Regulation of SREBP signaling pathway, Regulation of protein exit from endoplasmic reticulum, and Protein deubiquitination. Each is linked with SPCS3 in more than 13 cancer types. Because this analysis shows association rather than direction, both SPCS3-to-partner and partner-to-SPCS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of SREBP signaling pathway grouped by SPCS3-low versus SPCS3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPCS3→partner) and Y-score (partner→SPCS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of SREBP signaling pathway →	+0.108	+1.060	.003	.001	2	14
OESOPHAGUS	Regulation of protein exit from endoplasmic reticulum →	+0.144	+1.157	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Protein deubiquitination →	+0.055	+0.969	.002	.001	3	10
LUNG_NSCLC_LUAD	Positive regulation of SREBP signaling pathway →	+0.127	+0.927	<.001	<.001	3	10
LIVER	DNA synthesis involved in DNA replication →	+0.078	+1.250	<.001	.002	3	9
BONE	Peptidyl-lysine oxidation →	+1.429	+1.343	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,339 associations by consensus.

Regulation of SREBP signaling pathway by SPCS3 expression — BONE

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