SPCS2P1

Across TCGA patient cohorts, SPCS2P1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,384 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SPCS2P1-associated GO terms across cancer lineages are Rescue of stalled ribosome, Vesicle budding from membrane, and Regulation of mRNA catabolic process. Each is linked with SPCS2P1 in more than 14 cancer types. Because this analysis shows association rather than direction, both SPCS2P1-to-partner and partner-to-SPCS2P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rescue of stalled ribosome grouped by SPCS2P1-low versus SPCS2P1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPCS2P1→partner) and Y-score (partner→SPCS2P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Rescue of stalled ribosome →	+0.056	+0.197	<.001	<.001	3	15
STAD	Vesicle budding from membrane →	+0.060	+0.222	<.001	<.001	3	14
STAD	Regulation of mRNA catabolic process →	+0.046	+0.203	<.001	<.001	3	14
STAD	Double-strand break repair via nonhomologous end joining →	+0.050	+0.184	<.001	<.001	3	14
STAD	Positive regulation of telomere maintenance via telomere lengthening →	+0.057	+0.217	<.001	<.001	3	13
STAD	Regulation of ubiquitin-dependent protein catabolic process →	+0.056	+0.192	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,384 associations by consensus.

Rescue of stalled ribosome by SPCS2P1 expression — STAD

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