SPCS2

Across TCGA pan-cancer cohorts, SPCS2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SPCS2 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SPCS2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPCS2 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where SPCS2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	IV	0.131	0.861	.001	26	view →
HNSC	DFS	Quartile	All	0.823	0.538	.002	14	view →
LSCC	DFS	Median	II,III,IV	0.662	0.888	.021	3	view →
GBM	DFS	Median	All	0.287	0.437	.011	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SPCS2–CCRCC (DFS)

Open the CCRCC breakdown →