SPCS2

Across TCGA patient cohorts, SPCS2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPCS2-associated genes across cancer lineages are Annexin_VII, Caspase-7-cleavedD198, and c-Met_pY1235. Each is linked with SPCS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPCS2-to-partner and partner-to-SPCS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin_VII grouped by SPCS2-low versus SPCS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPCS2→partner) and Y-score (partner→SPCS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin_VII →	-0.166	-2.321	.017	.035	3	1
UCEC	Caspase-7-cleavedD198 →	+0.824	+2.827	.005	.035	3	1
UCEC	c-Met_pY1235 →	+0.098	+3.459	.008	.005	3	1
UCEC	p62 Lck ligand →	+0.330	+2.321	.043	.035	1	1
UCEC	Caspase-8 →	-0.267	-3.459	.034	.005	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Annexin_VII by SPCS2 expression — UCEC

Explore this box plot interactively →