SPCS2

Across TCGA cell cohorts, SPCS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,092 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SPCS2-associated GO terms across cancer lineages are Maintenance of organelle location, Maintenance of Golgi location, and Telomerase RNA localization to Cajal body. Each is linked with SPCS2 in more than 10 cancer types. Because this analysis shows association rather than direction, both SPCS2-to-partner and partner-to-SPCS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maintenance of organelle location grouped by SPCS2-low versus SPCS2-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPCS2→partner) and Y-score (partner→SPCS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Maintenance of organelle location →	+0.056	+0.723	.001	<.001	3	11
KIDNEY	Maintenance of Golgi location →	+0.082	+0.863	<.001	.001	3	9
URINARY_TRACT	Telomerase RNA localization to Cajal body →	-0.113	-0.727	.003	.008	3	8
URINARY_TRACT	Telomerase RNA localization →	-0.113	-0.727	.003	.008	3	8
UPPER_AERODIGESTIVE_TRACT	Centriole elongation →	+0.113	+1.258	.002	<.001	3	8
SOFT_TISSUE	Pyrimidine nucleoside biosynthetic process →	-0.077	-0.503	.006	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,092 associations by consensus.

Maintenance of organelle location by SPCS2 expression — BLOOD_Lymphoma

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