SPCS1

Across TCGA pan-cancer cohorts, SPCS1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SPCS1 data layer compared with 21 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SPCS1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SPCS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where SPCS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.807	0.531	.004	24	view →
LUAD	DFS	Quartile	All	0.998	0.855	.009	15	view →
LSCC	DFS	Median	II,III,IV	0.669	0.877	.013	12	view →
CCRCC	DFS	Tertile	IV	0.178	0.908	.038	12	view →
PDAC	DFS	Tertile	II,III,IV	0.594	0.322	.008	6	view →
COAD	DFS	Median	IV	1.000	0.605	.043	6	view →
GBM	OS	Median	All	0.619	0.454	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SPCS1–HNSC (DFS)

Open the HNSC breakdown →