SPCS1

Across TCGA patient cohorts, SPCS1 protein abundance is significantly associated with the RNA expression of many other genes, with 18,248 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPCS1-associated genes across cancer lineages are LAX1, IGHJ4, and IGKV2-26. Each is linked with SPCS1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SPCS1-to-partner and partner-to-SPCS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPCS1 versus LAX1 in LSCC, with a Pearson correlation of 0.80.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPCS1→partner) and Y-score (partner→SPCS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LAX1 →	+1.314	+0.652	<.001	<.001	3	6
HNSC	IGHJ4 →	+2.948	+0.683	<.001	<.001	3	6
COAD	IGKV2-26 →	+1.154	+0.337	<.001	<.001	3	6
LSCC	IFNG-AS1 →	+1.145	+0.650	<.001	<.001	3	6
LUAD	CD79A →	+1.570	+0.525	<.001	<.001	3	5
LUAD	POU2AF1 →	+1.267	+0.507	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,248 associations by consensus.

SPCS1 vs LAX1 — LSCC

Explore this scatter interactively →