SPCS1

Across TCGA patient cohorts, SPCS1 mutation is significantly associated with the RNA expression of many other genes, with 289 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPCS1-associated genes across cancer lineages are RNU6-13P, MIR548D2, and RN7SL237P. Each is linked with SPCS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPCS1-to-partner and partner-to-SPCS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-13P grouped by SPCS1-low versus SPCS1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPCS1→partner) and Y-score (partner→SPCS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-13P →	+0.281	+4.594	<.001	.008	3	2
UCEC	MIR548D2 →	+0.336	+3.279	<.001	.006	3	1
UCEC	RN7SL237P →	+0.399	+2.759	<.001	.002	3	1
UCEC	MIR5188 →	+0.884	+2.457	<.001	.005	3	1
UCEC	SDHDP1 →	+0.371	+2.801	<.001	.002	3	1
UCEC	WBP1LP6 →	+0.091	+4.075	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 289 associations by consensus.

RNU6-13P by SPCS1 expression — SKCM

Explore this box plot interactively →