SPCS1

Across TCGA patient cohorts, SPCS1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPCS1-associated genes across cancer lineages are EGFR_pY1068, VHL, and Tuberin. Each is linked with SPCS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPCS1-to-partner and partner-to-SPCS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SPCS1-low versus SPCS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPCS1→partner) and Y-score (partner→SPCS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.335	-3.000	.021	.037	3	1
UCEC	VHL →	-0.833	-3.000	.033	.037	3	1
UCEC	Tuberin →	+0.395	+3.000	.011	.037	2	1
UCEC	CD49b →	-0.434	-2.986	.008	.037	2	1
UCEC	c-Kit →	-0.311	-2.980	.021	.036	2	1
UCEC	Cyclin-E1 →	+0.625	+3.000	.013	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by SPCS1 expression — UCEC

Explore this box plot interactively →