SPCS1

Across TCGA cell cohorts, SPCS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,389 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SPCS1-associated GO terms across cancer lineages are Arginyl-tRNA aminoacylation, Regulation of L-glutamate import across plasma membrane, and tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation. Each is linked with SPCS1 in more than 11 cancer types. Because this analysis shows association rather than direction, both SPCS1-to-partner and partner-to-SPCS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Arginyl-tRNA aminoacylation grouped by SPCS1-low versus SPCS1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPCS1→partner) and Y-score (partner→SPCS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Arginyl-tRNA aminoacylation →	+0.198	+0.849	<.001	<.001	3	12
BONE	Regulation of L-glutamate import across plasma membrane →	+0.135	+0.471	.001	<.001	3	10
LUNG_SCLC	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation →	+0.086	+0.384	<.001	<.001	3	9
LUNG_SCLC	Granulocyte colony-stimulating factor signaling pathway →	+0.182	+0.455	<.001	.004	3	8
BLOOD_Leukemia	Establishment of protein localization to postsynaptic membrane →	+0.119	+0.456	<.001	<.001	3	8
BONE	Positive regulation of retrograde protein transport, ER to cytosol →	+0.132	+0.669	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,389 associations by consensus.

Arginyl-tRNA aminoacylation by SPCS1 expression — LIVER

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