SPC24

Across TCGA pan-cancer cohorts, SPC24 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SPC24 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SPC24 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SPC24 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where SPC24 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.467	0.753	.012	27	view →
LUAD	OS	Median	All	0.646	0.885	.002	9	view →
HNSC	DFS	Median	III,IV	0.911	0.992	.039	7	view →
OV	DFS	Median	All	0.869	1.000	.042	4	view →
UCEC	DFS	Tertile	All	1.000	0.933	.048	2	view →
CCRCC	OS	Median	All	1.000	0.703	.020	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SPC24–PDAC (OS)

Open the PDAC breakdown →