SPC24

Across TCGA patient cohorts, SPC24 protein abundance is significantly associated with the RNA expression of many other genes, with 17,412 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPC24-associated genes across cancer lineages are FAM72C, CDC25A, and CDCA4. Each is linked with SPC24 in more than 7 cancer types. Because this analysis shows association rather than direction, both SPC24-to-partner and partner-to-SPC24 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPC24 versus FAM72C in OV, with a Pearson correlation of 0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPC24→partner) and Y-score (partner→SPC24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FAM72C →	+0.926	+0.437	<.001	<.001	3	8
GBM	CDC25A →	+1.035	+0.728	<.001	<.001	3	8
HNSC	CDCA4 →	+0.799	+0.359	.002	<.001	3	8
UCEC	NCAPG →	+1.303	+0.579	<.001	<.001	3	8
OV	SHCBP1 →	+1.059	+0.589	<.001	<.001	3	8
UCEC	TPX2 →	+1.573	+0.603	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,412 associations by consensus.

SPC24 vs FAM72C — OV

Explore this scatter interactively →