Across TCGA patient cohorts, SPATS2L mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATS2L-associated genes across cancer lineages are MSH2, Notch1, and Caspase-7-cleavedD198. Each is linked with SPATS2L in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATS2L-to-partner and partner-to-SPATS2L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATS2L→partner) and Y-score (partner→SPATS2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.251	-1.880	.001	.014	3	2
UCEC	Notch1 →	+0.171	+2.097	<.001	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.839	+2.434	<.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.203	-1.807	.017	.004	3	1
UCEC	eIF4E →	+0.173	+3.472	.016	.002	3	1
UCEC	ACC1 →	+0.276	+1.807	.026	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

SPATS2L survival (RNA) · tumor vs normal (RNA) · all SPATS2L data types