SPATS2

Across TCGA cell cohorts, SPATS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,380 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPATS2-associated GO terms across cancer lineages are Nuclear transport, Nucleocytoplasmic transport, and Negative regulation of sister chromatid cohesion. Each is linked with SPATS2 in more than 14 cancer types. Because this analysis shows association rather than direction, both SPATS2-to-partner and partner-to-SPATS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear transport grouped by SPATS2-low versus SPATS2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATS2→partner) and Y-score (partner→SPATS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Nuclear transport →	+0.103	+1.257	.001	.001	3	15
OESOPHAGUS	Nucleocytoplasmic transport →	+0.102	+1.257	.001	.001	3	15
BLOOD_Lymphoma	Negative regulation of sister chromatid cohesion →	+0.091	+0.798	<.001	.001	3	13
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell cycle process →	+0.070	+0.893	<.001	<.001	3	12
LIVER	Import into nucleus →	+0.080	+0.780	.002	.006	2	13
LARGE_INTESTINE	DNA-templated transcription initiation →	+0.078	+0.982	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,380 associations by consensus.

Nuclear transport by SPATS2 expression — OESOPHAGUS

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