SPATC1L

Across TCGA cell cohorts, SPATC1L RNA expression is significantly associated with the go_rna of many other GO terms, with 2,004 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPATC1L-associated GO terms across cancer lineages are Regulation of smoothened signaling pathway, Canonical glycolysis, and Glucose catabolic process to pyruvate. Each is linked with SPATC1L in more than 7 cancer types. Because this analysis shows association rather than direction, both SPATC1L-to-partner and partner-to-SPATC1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of smoothened signaling pathway grouped by SPATC1L-low versus SPATC1L-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATC1L→partner) and Y-score (partner→SPATC1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of smoothened signaling pathway →	+0.044	+0.915	.002	.005	3	7
URINARY_TRACT	Canonical glycolysis →	+0.089	+1.732	.002	.002	3	7
URINARY_TRACT	Glucose catabolic process to pyruvate →	+0.089	+1.732	.002	.002	3	7
LIVER	Negative regulation of smoothened signaling pathway →	+0.071	+1.289	.001	.001	3	7
BONE	Regulation of sodium ion transport →	-0.135	-0.756	<.001	.002	2	8
OESOPHAGUS	Positive regulation of sodium ion transport →	-0.142	-1.183	.001	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,004 associations by consensus.

Regulation of smoothened signaling pathway by SPATC1L expression — OVARY

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