SPATC1L

Across TCGA cell cohorts, SPATC1L mutation is significantly associated with the mutation status of many other genes, with 3,442 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPATC1L-associated genes across cancer lineages are ARFGEF2, CDC42BPB, and PTCHD3. Each is linked with SPATC1L in more than 3 cancer types. Because this analysis shows association rather than direction, both SPATC1L-to-partner and partner-to-SPATC1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARFGEF2 grouped by SPATC1L-low versus SPATC1L-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATC1L→partner) and Y-score (partner→SPATC1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ARFGEF2 →	+3.975	+5.498	<.001	<.001	1	4
LUNG_NSCLC_LUAD	CDC42BPB →	+4.339	+5.303	<.001	<.001	1	4
LARGE_INTESTINE	PTCHD3 →	+2.284	+3.925	.005	.005	1	4
LUNG_NSCLC_LUAD	WIZ →	+4.339	+4.339	.009	.009	1	4
LUNG_SCLC	CSF3R →	+4.502	+5.066	.007	.007	1	4
BLOOD_Leukemia	FN1 →	+2.560	+4.364	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,442 associations by consensus.

ARFGEF2 by SPATC1L expression — BLOOD_Leukemia

Explore this box plot interactively →