Across TCGA pan-cancer cohorts, SPATC1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SPATC1 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SPATC1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPATC1 expression acts as an unfavorable survival marker.

ACC, KICH, and LIHC are the cancer types where SPATC1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.046	0.753	<.001	36	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
LIHC	OS	Median	II,III,IV	0.239	0.715	.035	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SPATC1 tumor-vs-normal RNA expression · all SPATC1 data types