Across TCGA patient cohorts, SPATC1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATC1-associated genes across cancer lineages are Caspase-8, p62 Lck ligand, and PDCD4. Each is linked with SPATC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATC1-to-partner and partner-to-SPATC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATC1→partner) and Y-score (partner→SPATC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Caspase-8 →	-0.174	-2.584	.009	.011	3	2
UCEC	p62 Lck ligand →	+0.384	+3.179	.011	.010	3	1
UCEC	PDCD4 →	-0.481	-2.584	.028	.011	3	1
UCEC	Rad50 →	-0.246	-2.584	.029	.011	3	1
UCEC	Annexin-1 →	+0.528	+2.827	.031	.035	3	1
UCEC	Src →	+0.256	+2.584	.007	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

SPATC1 survival (RNA) · tumor vs normal (RNA) · all SPATC1 data types