Across TCGA cell cohorts, SPATC1 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPATC1-associated genes across cancer lineages are PRSS58, HOXB1, and DEFA4. Each is linked with SPATC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATC1-to-partner and partner-to-SPATC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATC1→partner) and Y-score (partner→SPATC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PRSS58 →	+0.092	+5.000	<.001	.006	3	1
LARGE_INTESTINE	HOXB1 →	+0.023	+3.113	<.001	.004	3	1
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR51B4 →	+0.945	+3.614	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR4N4 →	+0.183	+3.604	<.001	.004	3	1
LUNG_NSCLC_LUAD	RNASE9 →	+0.015	+3.887	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

SPATC1 survival (RNA) · tumor vs normal (RNA) · all SPATC1 data types