SPATA9

Across TCGA patient cohorts, SPATA9 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA9-associated genes across cancer lineages are Notch1, ASNS, and EGFR_pY1068. Each is linked with SPATA9 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA9-to-partner and partner-to-SPATA9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SPATA9-low versus SPATA9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA9→partner) and Y-score (partner→SPATA9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.246	+2.817	<.001	.036	3	2
UCEC	ASNS →	+0.811	+3.459	<.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.269	-3.459	.033	.005	3	1
UCEC	HER3_pY1289 →	+0.086	+2.348	.047	.019	3	1
UCEC	Rab11 →	-0.207	-3.459	.004	.005	3	1
UCEC	Rab25 →	-0.417	-2.321	.012	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Notch1 by SPATA9 expression — UCEC

Explore this box plot interactively →