SPATA9

Across TCGA cell cohorts, SPATA9 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,260 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SPATA9-associated GO terms across cancer lineages are Regulation of proteolysis, Negative regulation of protein catabolic process, and Response to unfolded protein. Each is linked with SPATA9 in more than 9 cancer types. Because this analysis shows association rather than direction, both SPATA9-to-partner and partner-to-SPATA9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of proteolysis grouped by SPATA9-low versus SPATA9-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA9→partner) and Y-score (partner→SPATA9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of proteolysis →	+0.133	+0.496	<.001	<.001	3	10
STOMACH	Negative regulation of protein catabolic process →	+0.075	+0.330	.004	<.001	3	9
BONE	Response to unfolded protein →	+0.064	+0.302	.004	.007	3	9
BONE	Substrate adhesion-dependent cell spreading →	+0.169	+0.421	.001	.004	3	9
BONE	Small GTPase-mediated signal transduction →	+0.062	+0.537	.006	.004	3	9
BONE	Wound healing →	+0.152	+0.474	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,260 associations by consensus.

Regulation of proteolysis by SPATA9 expression — BONE

Explore this box plot interactively →