Across TCGA patient cohorts, SPATA8 mutation is significantly associated with the RNA expression of many other genes, with 1,085 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible SPATA8-associated genes across cancer lineages are OR4P4, OR2P1P, and HMGN2P5. Each is linked with SPATA8 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPATA8-to-partner and partner-to-SPATA8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA8→partner) and Y-score (partner→SPATA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OR4P4 →	+0.126	+3.356	<.001	.005	3	3
HNSC	OR2P1P →	+0.043	+4.655	<.001	.007	3	2
SKCM	HMGN2P5 →	+0.648	+2.743	<.001	<.001	3	2
SKCM	SUMO1P3 →	+0.457	+1.879	<.001	.004	3	2
LUSC	RPS3AP48 →	+0.259	+3.422	<.001	.009	3	2
BLCA	MIR30A →	+0.557	+7.640	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,085 associations by consensus.

Exploration

SPATA8 survival (RNA) · tumor vs normal (RNA) · all SPATA8 data types