Across TCGA patient cohorts, SPATA8 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SPATA8-associated genes across cancer lineages are Tuberin_pT1462, FoxM1, and p62 Lck ligand. Each is linked with SPATA8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA8-to-partner and partner-to-SPATA8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA8→partner) and Y-score (partner→SPATA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin_pT1462 →	+0.390	+2.817	.003	.036	3	1
SKCM	FoxM1 →	+0.239	+2.321	.019	.035	2	2
SKCM	p62 Lck ligand →	+0.422	+2.321	.028	.035	3	1
SKCM	AMPK_pT172 →	+0.355	+2.321	.030	.035	3	1
SKCM	S6 →	+0.638	+3.000	.004	.034	3	1
SKCM	VEGFR2 →	+0.293	+2.321	.030	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

SPATA8 survival (RNA) · tumor vs normal (RNA) · all SPATA8 data types