SPATA8-AS1

Across TCGA pan-cancer cohorts, SPATA8-AS1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated SPATA8-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SPATA8-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPATA8-AS1 expression acts as an unfavorable survival marker, although some lineages such as CESC show a favorable association.

KIRC, LUSC, and TGCT are the cancer types where SPATA8-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	II,III,IV	0.463	0.697	.003	60	view →
LUSC	DFS	Tertile	II,III,IV	0.338	0.726	<.001	54	view →
TGCT	DFS	Tertile	II,III,IV	0.674	1.000	.007	48	view →
LUAD	DFS	Tertile	IV	0.342	0.893	<.001	45	view →
KICH	DFS	Tertile	III,IV	0.043	0.774	.005	36	view →
THCA	DFS	Tertile	III,IV	0.106	0.634	.002	30	view →
CESC	DFS	Tertile	All	1.000	0.517	.026	18	view →
LAML	DFS	Tertile	All	0.153	0.589	.025	18	view →
UCS	OS	Tertile	IV	0.269	0.624	.042	18	view →
THYM	DFS	Tertile	All	0.180	0.738	<.001	12	view →
SKCM	DFS	Tertile	III,IV	0.080	0.260	.023	12	view →
STAD	DFS	Tertile	II,III,IV	0.465	0.724	.007	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

SPATA8-AS1–KIRC (DFS)

Open the KIRC breakdown →