SPATA6

Across TCGA pan-cancer cohorts, SPATA6 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SPATA6 data layer compared with 19 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher SPATA6 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SPATA6 expression acts as an unfavorable survival marker, although some lineages such as STAD show a favorable association.

STAD, LIHC, and LUAD are the cancer types where SPATA6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Median	II,III,IV	1.000	0.344	.037	19	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	12	view →
LUAD	OS	Median	II,III,IV	0.141	0.709	<.001	12	view →
SKCM	OS	Median	IV	0.179	0.755	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SPATA6–STAD (DFS)

Open the STAD breakdown →