SPATA6

Across TCGA patient cohorts, SPATA6 mutation is significantly associated with the RNA expression of many other genes, with 962 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA6-associated genes across cancer lineages are IQCF5, RNU6-1150P, and RN7SL199P. Each is linked with SPATA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA6-to-partner and partner-to-SPATA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by SPATA6-low versus SPATA6-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA6→partner) and Y-score (partner→SPATA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IQCF5 →	+0.066	+5.000	<.001	.003	3	2
LUAD	RNU6-1150P →	+0.404	+4.684	<.001	.001	3	2
LUAD	RN7SL199P →	+0.151	+4.502	<.001	.007	3	2
BRCA	EEF1A1P40 →	+0.088	+5.441	.008	.005	3	2
UCEC	MIR8070 →	+0.637	+1.939	<.001	.007	3	2
HNSC	LINC01656 →	+0.084	+4.916	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 962 associations by consensus.

IQCF5 by SPATA6 expression — LUAD

Explore this box plot interactively →