SPATA6

Across TCGA patient cohorts, SPATA6 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA6-associated genes across cancer lineages are 14-3-3_beta, ACC_pS79, and GATA6. Each is linked with SPATA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA6-to-partner and partner-to-SPATA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by SPATA6-low versus SPATA6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA6→partner) and Y-score (partner→SPATA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.129	-3.295	.004	.009	3	1
UCEC	ACC_pS79 →	+0.409	+3.009	.008	.019	3	1
UCEC	GATA6 →	-0.208	-3.155	.002	.018	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.449	+2.331	.019	.019	3	1
UCEC	INPP4B →	-0.356	-2.459	.014	.019	3	1
UCEC	JNK2 →	+0.257	+2.700	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

14-3-3_beta by SPATA6 expression — UCEC

Explore this box plot interactively →