SPATA6

Across TCGA cell cohorts, SPATA6 mutation is significantly associated with the RNA expression of many other genes, with 48 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SPATA6-associated genes across cancer lineages are CEACAM3, MEIKIN, and APCS. Each is linked with SPATA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA6-to-partner and partner-to-SPATA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEACAM3 grouped by SPATA6-low versus SPATA6-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA6→partner) and Y-score (partner→SPATA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CEACAM3 →	+0.021	+4.000	.003	.008	3	2
BONE	MEIKIN →	+0.037	+4.169	<.001	.008	3	2
LUNG_SCLC	APCS →	+0.034	+4.058	<.001	.007	3	2
SOFT_TISSUE	C20orf85 →	+0.115	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR1L4 →	+0.072	+5.369	<.001	.004	3	1
SOFT_TISSUE	PRKACG →	+0.006	+5.369	.009	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

CEACAM3 by SPATA6 expression — BONE

Explore this box plot interactively →