SPATA5L1

Across TCGA pan-cancer cohorts, SPATA5L1 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of SPATA5L1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SPATA5L1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SPATA5L1 is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

LUAD, LSCC, and HNSC are the cancer types where SPATA5L1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPATA5L1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−0.338	<.001	9	view →
LSCC	All	III,IV	−0.184	<.001	8	view →
HNSC	All	All	−0.173	<.001	8	view →
COAD	Male	III,IV	−0.309	<.001	6	view →
PDAC	Female	All	−0.338	<.001	5	view →
OV	All	All	−0.243	.031	2	view →
CCRCC	Male	All	+0.061	.010	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

SPATA5L1–LUAD

Open the LUAD breakdown →