SPATA5L1

Across TCGA patient cohorts, SPATA5L1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA5L1-associated genes across cancer lineages are GAPDH, ASNS, and Notch1. Each is linked with SPATA5L1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPATA5L1-to-partner and partner-to-SPATA5L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by SPATA5L1-low versus SPATA5L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA5L1→partner) and Y-score (partner→SPATA5L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.567	+3.169	.012	.018	3	3
UCEC	ASNS →	+0.691	+3.584	<.001	.002	3	3
UCEC	Notch1 →	+0.247	+2.906	<.001	.001	3	2
UCEC	ATM →	-0.770	-2.906	<.001	.001	3	2
UCEC	eIF4G →	+0.333	+3.169	.011	.018	3	1
UCEC	A-Raf_pS299 →	-0.122	-2.459	.016	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

GAPDH by SPATA5L1 expression — UCEC

Explore this box plot interactively →