SPATA5L1

Across TCGA cell cohorts, SPATA5L1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPATA5L1-associated genes across cancer lineages are BPIFB6, TRH, and HSF5. Each is linked with SPATA5L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA5L1-to-partner and partner-to-SPATA5L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPIFB6 grouped by SPATA5L1-low versus SPATA5L1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA5L1→partner) and Y-score (partner→SPATA5L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BPIFB6 →	+0.014	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TRH →	+0.078	+3.334	.001	.008	3	1
LARGE_INTESTINE	HSF5 →	+0.028	+3.321	.007	.002	3	1
LARGE_INTESTINE	OR2D3 →	+0.019	+2.925	.002	.007	3	1
LARGE_INTESTINE	ADH1B →	+0.045	+3.617	.004	.004	3	1
LARGE_INTESTINE	ANKRD63 →	+0.298	+3.700	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

BPIFB6 by SPATA5L1 expression — LARGE_INTESTINE

Explore this box plot interactively →