SPATA5

Across TCGA patient cohorts, SPATA5 protein abundance is significantly associated with the RNA expression of many other genes, with 8,642 significant associations in total. COAD shows the largest number of these associations.

The most reproducible SPATA5-associated genes across cancer lineages are EXOSC9, ZGRF1, and AP1AR. Each is linked with SPATA5 in more than 5 cancer types. Because this analysis shows association rather than direction, both SPATA5-to-partner and partner-to-SPATA5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPATA5 versus EXOSC9 in COAD, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA5→partner) and Y-score (partner→SPATA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EXOSC9 →	+0.681	+0.307	<.001	<.001	3	6
OV	ZGRF1 →	+0.698	+0.276	<.001	<.001	3	6
BRCA	AP1AR →	+0.658	+0.312	<.001	<.001	3	6
OV	SPATA5L1 →	+0.646	+0.248	<.001	<.001	3	6
LSCC	GAR1 →	+0.477	+0.203	<.001	.006	3	5
UCEC	LARP1B →	+0.543	+0.253	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,642 associations by consensus.

SPATA5 vs EXOSC9 — COAD

Explore this scatter interactively →