SPATA5

Across TCGA patient cohorts, SPATA5 mutation is significantly associated with the RNA expression of many other genes, with 3,668 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA5-associated genes across cancer lineages are RPL39P33, BCS1L, and ME2. Each is linked with SPATA5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPATA5-to-partner and partner-to-SPATA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL39P33 grouped by SPATA5-low versus SPATA5-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA5→partner) and Y-score (partner→SPATA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL39P33 →	+0.257	+2.615	.002	.008	3	3
UCEC	BCS1L →	+0.229	+1.743	.009	.001	3	3
UCEC	ME2 →	+0.414	+2.353	.002	.003	3	3
UCEC	TOMM22 →	+0.313	+1.721	.005	.001	3	3
UCEC	SRP54 →	+0.416	+2.365	.002	.002	3	3
UCEC	EIF2B2 →	+0.415	+2.627	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,668 associations by consensus.

RPL39P33 by SPATA5 expression — LUAD

Explore this box plot interactively →