SPATA5

Across TCGA patient cohorts, SPATA5 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA5-associated genes across cancer lineages are Gab2, MEK1, and p38-MAPK_pT180_Y182. Each is linked with SPATA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA5-to-partner and partner-to-SPATA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by SPATA5-low versus SPATA5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA5→partner) and Y-score (partner→SPATA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.300	+1.700	.009	.042	3	2
UCEC	MEK1 →	+0.449	+2.000	<.001	<.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.394	-1.446	.006	.012	3	2
UCEC	PDCD4 →	-0.506	-2.415	<.001	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.625	+2.189	.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.205	-1.459	.011	.012	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Gab2 by SPATA5 expression — UCEC

Explore this box plot interactively →