Across TCGA patient cohorts, SPATA45 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SPATA45-associated genes across cancer lineages are MIR6133, FECHP1, and NIPA2P5. Each is linked with SPATA45 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA45-to-partner and partner-to-SPATA45 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA45→partner) and Y-score (partner→SPATA45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR6133 →	+0.391	+5.867	<.001	.003	3	1
SKCM	FECHP1 →	+0.041	+6.199	<.001	.001	3	1
SKCM	NIPA2P5 →	+0.106	+6.199	<.001	.001	3	1
SKCM	AK4P2 →	+0.068	+5.037	.001	.009	3	1
UCEC	PPP1R26P4 →	+0.006	+4.555	<.001	.005	3	1
SKCM	MT-TD →	+0.563	+5.771	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

SPATA45 survival (RNA) · tumor vs normal (RNA) · all SPATA45 data types